Formulation Design and Optimization of Poly-herbal Chewable Tablets Using JMP Tool

Department of Pharmacognosy, KLE College of Pharmacy , KLE Academy of Higher Education and Research Nehru Nagar ,  Belagavi - 590010,  Karnataka, India

*Corresponding Author: Dr. Pramod HJ, Professor, Department of Pharmacognosy, KLE College of Pharmacy, KLE Academy of Higher Education and Research, Nehru Nagar, Belagavi - 590010, Karnataka, India; Tel: 9448244252; Email: [email protected]

Received Date: May 17, 2023

Publication Date:  October 21, 2023

Citation: Channi NM, et al. (2023). Formulation Design and Optimization of Poly-Herbal Chewable Tablet Using Jmp Tool. Pharmacogn. 2(1):3.

Copyright: Channi NM, et al. © (2023). 

ABSTRACT

Background and Objectives: Usage of traditional medicines increases when conventional medicines are ineffective. The present study was aimed to develop a formulation design and optimization of poly-herbal chewable tablet using different medicinal plant extracts against infectious disease.  Methods: A total of eight medicinal plants were selected and named Myrica nagi (M. nagi), Clerodendrum serratum (C. serratum), Inula racemose (I. racemose), Piper nigrum (P. nigrum), Terminalia bellerica (T. bellerica), Pistacia integerrima (P. integerrima), Solanum indicum (S. indicum), Acacia catechu (A. catechu). These plants are extracted separately. We designed the development of poly-herbal chewable tablets using JMP software and investigated the antimicrobial activity of the optimized poly-herbal chewable tablet. Results: The antimicrobial activity of the optimized poly-herbal chewable tablet was investigated and the formulation development of the poly-herbal chewable tablets was designed using the JMP Trial 16.0 software. The pre-formulation and post-formulation parameters studied show that the CT 07, CT 09, and CT 11 formulations show best results from all the formulations were designed. Stability study results that optimized poly-herbal chewable tablet were stable throughout the study. Interpretation & Conclusion: the outcome of the formulation show that CT 07, CT 09 and CT 11 are the better formulations, all the extracts have antimicrobial activity against infectious disease and have a positive effect on the treatment of upper respiratory tract infection, based upon the tablet evaluation parameters. 

Keywords: Anti-microbial activity, Chewable tablet, Polyherbal, JMP Software